It appears your prompt is describing "Step Two" of a

It appears your prompt is describing "Step Two" of a Twelve-Step program (like Alcoholics Anonymous) and then asking a series of "why, what, when, and where" hypothesis questions related to the concept of "How that must be overcome."
Based on the context provided about overcoming "twisted thought" and achieving a "right relation to God," here is a breakdown of potential hypotheses concerning how the unmanageable life (addictive behavior/self-centeredness) must be overcome.
:bulb: Hypotheses on Overcoming the Unmanageable Life
The core method for overcoming the "unmanageable life" in this framework is a Spiritual Solution to a Spiritual Malady (self-centeredness).
Why Hypothesis? (Focus on Motivation and Root Cause)

  • Why must it be overcome? The hypothesis is that the unmanageable life must be overcome because self-centeredness (the "spiritual malady") is the root cause of the individual's suffering and addiction. The continuation of this state leads to insanity, isolation, and eventually death or institutionalization. Overcoming it is necessary for survival and sanity.
  • Why is a Higher Power necessary? The hypothesis is that the self-centered will of the individual is powerless to overcome the addiction, so a Power greater than themselves (the Higher Power) is required to "restore them to sanity."
    What Hypothesis? (Focus on Method and Goal)
  • What is the primary method of overcoming? The hypothesis is that overcoming occurs through a spiritual awakening achieved by establishing a "right relation to God/Higher Power" (Step Two's goal). This is the "specific antidote" to the spiritual malady.
  • What is the result of overcoming? The hypothesis is that the result is a release from self-centeredness, a state of sobriety (a new "way of life"), and a restoration of sanity and kinship with others.
    When Hypothesis? (Focus on Timing and Process)
  • When does overcoming begin? The hypothesis is that the process of overcoming (moving toward sanity) begins when the individual admits to powerlessness (Step One) and then makes a decision to believe that a Higher Power can help (Step Two).
  • When is the unmanageable life truly overcome? The hypothesis is that it is never fully "overcome" in a final sense, but rather is maintained daily through a "way of life" that involves continuous conscious contact with the Higher Power and the practice of these principles in all affairs (Steps Ten, Eleven, and Twelve).
    Where Hypothesis? (Focus on Location and Context)
  • Where does the overcoming happen? The hypothesis is that the overcoming happens within the individual's consciousness and spirit (internal change) and is practiced in their daily life and relationships (external application), particularly within a community of others seeking the same goal (kinship/fellowship).
  • Where is the "rallying point to sanity"? The hypothesis is that the initial rallying point is the acceptance of the concept of the Higher Power (Step Two), moving the fight out of the self and into the spiritual realm.
    Would you like me to elaborate on one of these specific hypotheses, or describe the next step in the Twelve-Step process?